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CHS-828

Catalog No.: 100904
Cas No.: 200484-11-3
Purity : 98% 
100904 - CHS-828 | CAS 200484-11-3

Catalog number : 100904

CAS number : 200484-11-3

分子式 : C19H22ClN5O 

分子量 : 371.86 

Iupac 化学名称 : (E)-1-(6-(4-chlorophenoxy)hexyl)-2-cyano-3-(pyridin-4-yl)guanidine 

Smile : ClC1=CC=C(OCCCCCCN/C(=N\C#N)/NC2=CC=NC=C2)C=C1

InChiKey : BOIPLTNGIAPDBY-UHFFFAOYSA-N

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同义词CHS 828; CHS828; GMX-1778; GMX1778; GMX 1778 
英文同义词CHS 828; CHS828; GMX-1778; GMX1778; GMX 1778 
分子式C19H22ClN5O 
分子量371.86 
外观Solid powder 
纯度98% 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileClC1=CC=C(OCCCCCCN/C(=N\C#N)/NC2=CC=NC=C2)C=C1
InChiKeyBOIPLTNGIAPDBY-UHFFFAOYSA-N
InChiInChI=1S/C19H22ClN5O/c20-16-5-7-18(8-6-16)26-14-4-2-1-3-11-23-19(24-15-21)25-17-9-12-22-13-10-17/h5-10,12-13H,1-4,11,14H2,(H2,22,23,24,25)
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CHS-828, also known as GMX-1778, is a potent and selective NAMPT inhibitor. CHS-828 inhibits cellular synthesis of NAD. CHS 828 kill tumour cells by inhibiting the nuclear factor-kappaB translocation but unlikely through down-regulation of proteasome. CHS 828 has shown promising anticancer activity in experimental tumor models and primary cultures of cancer cells from patients. 

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