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CHIR-98014

Catalog No.: 5121103
Cas No.: 252935-94-7
Purity : 98% by HPLC 
5121103 - CHIR-98014 | CAS 252935-94-7

Catalog number : 5121103

CAS number : 252935-94-7

分子式 : C20H17Cl2N9O2 

分子量 : 486.31 

Iupac 化学名称 : N6-[ 2-[4-(2,4-DICHLORO-PHENYL)-5-IMIDAZOL-1-YL-PYRIMIDIN-2-YLAMINO]-ETHYL]-3-NITRO-PYRIDINE-2,6-DIAMINE 

Smile : NC1=NC(NCCNC2=NC=C(N3C=CN=C3)C(C4=CC=C(Cl)C=C4Cl)=N2)=CC=C1[N+]([O-])=O

InChiKey : MDZCSIDIPDZWKL-UHFFFAOYSA-N

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同义词CHIR98014;CHIR 98014 
英文同义词CHIR98014;CHIR 98014 
分子式C20H17Cl2N9O2 
分子量486.31 
外观crystalline solid 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder;6 months-80ºCin solvent 
运输条件Shipped under ambient temperature. 
SmileNC1=NC(NCCNC2=NC=C(N3C=CN=C3)C(C4=CC=C(Cl)C=C4Cl)=N2)=CC=C1[N+]([O-])=O
InChiKeyMDZCSIDIPDZWKL-UHFFFAOYSA-N
InChiInChI=1S/C20H17Cl2N9O2/c21-12-1-2-13(14(22)9-12)18-16(30-8-7-24-11-30)10-27-20(29-18)26-6-5-25-17-4-3-15(31(32)33)19(23)28-17/h1-4,7-11H,5-6H2,(H3,23,25,28)(H,26,27,29)
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CHIR98014 is a reversible, cell-permeable activator of the WNT pathway, through inhibition of both isoforms of glycogen synthase kinase 3 (GSK3 and GSK3) with IC₅₀ values of 0.65 and 0.58 nM, respectively. It shows at least 500-fold selectivity for GSK-3 versus 20 other serine/threonine or tyrosine kinases (Ring et al.).

 

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