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CB-839

Catalog No.: 16122913
Cas No.: 1439399-58-2
Purity : 98% 
16122913 - CB-839 | CAS 1439399-58-2

Catalog number : 16122913

CAS number : 1439399-58-2

分子式 : C26H24F3N7O3S 

分子量 : 571.57 

Iupac 化学名称 : CB-839 

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同义词CB839; CB-839; CB 839 
英文同义词CB839; CB-839; CB 839 
分子式C26H24F3N7O3S 
分子量571.57 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
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CB-839 an is orally bioavailable inhibitor of glutaminase, with potential antineoplastic activity. Upon oral administration, CB-839 selectively and irreversibly inhibits glutaminase, a mitochondrial enzyme that is essential for the conversion of the amino acid glutamine into glutamate. By blocking glutamine utilization, proliferation in rapidly growing cells is impaired. Glutamine-dependent tumors rely on the conversion of exogenous glutamine into glutamate and glutamate metabolites to both provide energy and generate building blocks for the production of macromolecules, which are needed for cellular growth and survival. 

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