CADD522
编号: 2051505
Cas号: 199735-88-1
纯度: 98% Min.
CADD522 is a potent inhibitor of runt-related transcription factor-2 (RUNX2)-DNA binding with an IC50 of 10 nM. CADD522 treatment resulted in significant growth inhibition, clonogenic survival, tumorsphere formation, and invasion of breast cancer cells. CADD522 negatively regulated transcription of RUNX2 target genes such as matrix metalloproteinase-13, vascular endothelial growth factor and glucose transporter-1, but upregulated RUNX2 expression by increasing RUNX2 stability. CADD522 reduced RUNX2-mediated increases in glucose uptake and decreased the level of CBF-β and RUNX2 phosphorylation at the S451 residue.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | CADD522 |
|---|---|
| Iupac 化学名称 | 3-((3,4-dichlorophenyl)carbamoyl)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid |
| 同义词 | CADD522; CADD-522; CADD 522; |
| 英文同义词 | CADD522; CADD-522; CADD 522; |
| 分子式 | C15H13Cl2NO3 |
| 分子量 | 326.173 |
| Smile | ClC1=C(Cl)C=CC(NC(C2C(C3)C=CC3C2C(O)=O)=O)=C1 |
| InChiKey | YSDNWNOGHQYWPK-UHFFFAOYSA-N |
| InChi | InChI=1S/C15H13Cl2NO3/c16-10-4-3-9(6-11(10)17)18-14(19)12-7-1-2-8(5-7)13(12)15(20)21/h1-4,6-8,12-13H,5H2,(H,18,19)(H,20,21) |
| Cas号 | 199735-88-1 |
| 相关CAS号 |
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