C-DIM12
编号: 16122915
Cas号: 178946-89-9
纯度: 98%
C-DIM12 is a novel synthetic activator of Nurr1. C-DIM12 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro. C-DIM12 activates Nurr1 in cancer cells and prevents loss of dopaminergic neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of PD in mice. C-DIM12 induced expression of Nurr1-regulated genes that was abolished by Nurr1 knockdown. C-DIM12 increased expression of transfected human Nurr1, induced Nurr1 protein expression in primary dopaminergic neurons and enhanced neuronal survival from exposure to 6-OHDA. C-DIM12 stimulates neuroprotective expression Nurr1-regulated genes in DA neurons.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | C-DIM12 |
|---|---|
| Iupac 化学名称 | C-DIM12 |
| 同义词 | C-DIM 12; C-DIM-12 |
| 英文同义词 | C-DIM 12; C-DIM-12 |
| 分子式 | C23H17ClN2 |
| 分子量 | 356.853 |
| InChiKey | |
| InChi | |
| Cas号 | 178946-89-9 |
| 相关CAS号 |
订购信息
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