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Brigatinib (AP-26113)

Catalog No.: 16122905
Cas No.: 1197953-54-0
Purity : 98% 
16122905 - Brigatinib (AP-26113) | CAS 1197953-54-0

Catalog number : 16122905

CAS number : 1197953-54-0

分子式 : C29H39ClN7O2P 

分子量 : 584.10176 

Iupac 化学名称 : Brigatinib (AP-26113) 

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同义词AP26113; AP-26113; AP 26113 
英文同义词AP26113; AP-26113; AP 26113 
分子式C29H39ClN7O2P 
分子量584.10176 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
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Brigatinib, also known as AP-26113, is an orally active, potent and selective Dual ALK/EGFR inhibitor. AP26113 binds to and inhibits ALK kinase and ALK fusion proteins as well as EGFR and mutant forms. This leads to the inhibition of ALK kinase and EGFR kinase, disrupts their signaling pathways and eventually inhibits tumor cell growth in susceptible tumor cells. In addition, AP26113 appears to overcome mutation-based resistance. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development; ALK dysregulation and gene rearrangements are associated with a series of tumors. EGFR is overexpressed in a variety of cancer cell types. 

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