Bezuclastinib is an oral, small-molecule inhibitor of the kinase activity of the KIT D816V mutant, as well as that of other KIT exon 17 mutants.
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| Name | Bezuclastinib |
|---|---|
| Iupac Chemical Name | 4,5-Dimethyl-N-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazole-3-carboxamide |
| Synonyms | Bezuclastinib ; CGT9486 ; PLX 9486 ; CGT 9486; PLX9486 ; CGT-9486; PLX-9486 |
| 英文同义词 | Bezuclastinib ; CGT9486 ; PLX 9486 ; CGT 9486; PLX9486 ; CGT-9486; PLX-9486 |
| Molecular Formula | C19H17N5O |
| Molecular Weight | 331.38 |
| Smile | O=C(C1=NNC(C)=C1C)NC2=CN=C(NC(C3=CC=CC=C3)=C4)C4=C2 |
| InChiKey | NVSHVYGIYPBTEZ-UHFFFAOYSA-N |
| InChi | InChI=1S/C19H17N5O/c1-11-12(2)23-24-17(11)19(25)21-15-8-14-9-16(22-18(14)20-10-15)13-6-4-3-5-7-13/h3-10H,1-2H3,(H,20,22)(H,21,25)(H,23,24) |
| CAS Number | 1616385-51-3 |
| 相关CAS号 | 1616385-51-3 |
| 包装 | Price | 库存 | Purity | 备货期 |
|---|---|---|---|---|
| 大货 | Enquiry | Enquiry | Enquiry |
| 外观性状 | Solid powder |
|---|---|
| Purity | ≧98.0% |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO (DMSO : ≥ 100 mg/mL) |
| 处理方式 | Refer to MSDS |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| 海关编码 | 2934200090 |
| Targets | c-kit Inhibitor |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |