BP-1-102
编号: 17030606
Cas号: 1334493-07-0
纯度: 98%
BP-1-102 is a potent, orally bioavailable and selective STAT3 inhibitor. BP-1-102 binds Stat3 with an affinity (K(D)) of 504 nM, blocks Stat3-phospho-tyrosine (pTyr) peptide interactions and Stat3 activation at 4-6.8 M, and selectively inhibits growth, survival, migration, and invasion of Stat3-dependent tumor cells. BP-1-102-mediated inhibition of aberrantly active Stat3 in tumor cells suppresses the expression of c-Myc, Cyclin D1, Bcl-xL, Survivin, VEGF, and Krüppel-like factor 8, which is identified as a Stat3 target gene that promotes Stat3-mediated breast tumor cell migration and invasion.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | BP-1-102 |
|---|---|
| Iupac 化学名称 | 4-(N-(4-cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid |
| 同义词 | BP-1-102; BP1-102; BP 1-102; BP1102; BP-1102; BP 1102 |
| 英文同义词 | BP-1-102; BP1-102; BP 1-102; BP1102; BP-1102; BP 1102 |
| 分子式 | C29H27F5N2O6S |
| 分子量 | 626.59 |
| Smile | C1(CCCCC1)C1=CC=C(CN(C(CN(S(=O)(=O)C2=C(C(=C(C(=C2F)F)F)F)F)C)=O)C2=CC(=C(C(=O)O)C=C2)O)C=C1 |
| InChiKey | WNVSFFVDMUSXSX-UHFFFAOYSA-N |
| InChi | InChI=1S/C29H27F5N2O6S/c1-35(43(41,42)28-26(33)24(31)23(30)25(32)27(28)34)15-22(38)36(19-11-12-20(29(39)40)21(37)13-19)14-16-7-9-18(10-8-16)17-5-3-2-4-6-17/h7-13,17,37H,2-6,14-15H2,1H3,(H,39,40) |
| Cas号 | 1334493-07-0 |
| 相关CAS号 |
订购信息
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