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BNC105

Catalog No.: 6111023
Cas No.: 945771-74-4
Purity : 98% 
6111023 - BNC105 | CAS 945771-74-4

Catalog number : 6111023

CAS number : 945771-74-4

分子式 : C20H20O7 

分子量 : 372.37 

Iupac 化学名称 : BNC105 

Smile : Cc1c(c2ccc(c(c2o1)O)OC)C(=O)c3cc(c(c(c3)OC)OC)OC

InChiKey : RADMJHVVIZTENA-UHFFFAOYSA-N

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同义词BNC-105 
英文同义词BNC-105 
分子式C20H20O7 
分子量372.37 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
SmileCc1c(c2ccc(c(c2o1)O)OC)C(=O)c3cc(c(c(c3)OC)OC)OC
InChiKeyRADMJHVVIZTENA-UHFFFAOYSA-N
InChiInChI=1S/C20H20O7/c1-10-16(12-6-7-13(23-2)18(22)19(12)27-10)17(21)11-8-14(24-3)20(26-5)15(9-11)25-4/h6-9,22H,1-5H3
MDLMFCD22628798
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BNC105 is a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.


BNC105 exhibited excellent potency against a panel of different cancer cell lines with IC50 <1 nM for DU145, Calu-6, MDA-MB-231 etc. The selectivity observed for BNC105 against activated over quiescent HUVECs was also observed in human aortic arterial endothelial cells (HAAECs). BNC105 also exhibited good potency toward the cisplatin resistant cell line A2780cis.



 

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