BMS-687453
编号: 16122902
Cas号: 1000998-59-3
纯度: 98%
BMS-687453 is a potent and selective peroxisome proliferator activated receptor (PPAR) alpha agonist. with an EC(50) of 10 nM for human PPARalpha and approximately 410-fold selectivity vs human PPARgamma in PPAR-GAL4 transactivation assays. BMS-687453 demonstrated an excellent pharmacological and safety profile in preclinical studies and thus was chosen as a development candidate for the treatment of atherosclerosis and dyslipidemia.
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化学信息
| 名称 | BMS-687453 |
|---|---|
| Iupac 化学名称 | BMS-687453 |
| 同义词 | BMS 687453; BMS687453 |
| 英文同义词 | BMS 687453; BMS687453 |
| 分子式 | C22H21ClN2O6 |
| 分子量 | 444.868 |
| Smile | Cc1c(nc(o1)c2ccc(cc2)Cl)COc3cccc(c3)CN(CC(=O)O)C(=O)OC |
| InChiKey | UJIBXDMNCMEJAY-UHFFFAOYSA-N |
| InChi | InChI=1S/C22H21ClN2O6/c1-14-19(24-21(31-14)16-6-8-17(23)9-7-16)13-30-18-5-3-4-15(10-18)11-25(12-20(26)27)22(28)29-2/h3-10H,11-13H2,1-2H3,(H,26,27) |
| Cas号 | 1000998-59-3 |
| MDL | MFCD18251482 |
| 相关CAS号 |
订购信息
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| 大货 | 询价 | 询价 | 询价 |
