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BMS-582949 编号 : 16062903

化学信息

产品英文名称BMS-582949
Iupac 化学名称4-((5-(cyclopropylcarbamoyl)-2-methylphenyl)amino)-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide 
同义词BMS-582949; BMS 582949; 
英文同义词BMS-582949; BMS 582949; 
分子式C22H26N6O2 
分子量406.49 
SmileC1(CC1)NC(=O)C=1C=CC(=C(C1)NC1=NC=NN2C1=C(C(=C2)C(=O)NCCC)C)C
InChiKeyGDTQLZHHDRRBEB-UHFFFAOYSA-N
InChiInChI=1S/C22H26N6O2/c1-4-9-23-22(30)17-11-28-19(14(17)3)20(24-12-25-28)27-18-10-15(6-5-13(18)2)21(29)26-16-7-8-16/h5-6,10-12,16H,4,7-9H2,1-3H3,(H,23,30)(H,26,29)(H,24,25,27)
Cas623152-17-0

技术数据

外观Solid powder 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
质量控制

产品详情

BMS-582949 is a potent and selective P38 mitogen-activated protein kinase (P38 MAPK) inhibitor. BMS-582949 is currently under Phase II clinical trials for the treatment of inflammatory diseases. One clinical study showed that, in stable atherosclerosis, 12 weeks of treatment with BMS-582949 did not reduce arterial inflammation or hs-CRP compared to placebo, whereas intensification of statin therapy significantly decreased arterial inflammation. p38 MAP kinase plays a crucial role in regulating the biosynthesis of many inflammatory cytokines including TNF and IL-1 

结构

16062903 - BMS-582949 | CAS 623152-17-0

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