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BMS-582949

Catalog No.: 16062903
Cas No.: 623152-17-0
Purity : 98% by HPLC 
16062903 - BMS-582949 | CAS 623152-17-0

Catalog number : 16062903

CAS number : 623152-17-0

分子式 : C22H26N6O2 

分子量 : 406.49 

Iupac 化学名称 : 4-((5-(cyclopropylcarbamoyl)-2-methylphenyl)amino)-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide 

Smile : C1(CC1)NC(=O)C=1C=CC(=C(C1)NC1=NC=NN2C1=C(C(=C2)C(=O)NCCC)C)C

InChiKey : GDTQLZHHDRRBEB-UHFFFAOYSA-N

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同义词BMS-582949; BMS 582949; 
英文同义词BMS-582949; BMS 582949; 
分子式C22H26N6O2 
分子量406.49 
外观Solid powder 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileC1(CC1)NC(=O)C=1C=CC(=C(C1)NC1=NC=NN2C1=C(C(=C2)C(=O)NCCC)C)C
InChiKeyGDTQLZHHDRRBEB-UHFFFAOYSA-N
InChiInChI=1S/C22H26N6O2/c1-4-9-23-22(30)17-11-28-19(14(17)3)20(24-12-25-28)27-18-10-15(6-5-13(18)2)21(29)26-16-7-8-16/h5-6,10-12,16H,4,7-9H2,1-3H3,(H,23,30)(H,26,29)(H,24,25,27)
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BMS-582949 is a potent and selective P38 mitogen-activated protein kinase (P38 MAPK) inhibitor. BMS-582949 is currently under Phase II clinical trials for the treatment of inflammatory diseases. One clinical study showed that, in stable atherosclerosis, 12 weeks of treatment with BMS-582949 did not reduce arterial inflammation or hs-CRP compared to placebo, whereas intensification of statin therapy significantly decreased arterial inflammation. p38 MAP kinase plays a crucial role in regulating the biosynthesis of many inflammatory cytokines including TNF and IL-1 

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