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BMS-3

Catalog No.: 16071026
Cas No.: 1338247-30-5
Purity : 98% by HPLC 
16071026 - BMS-3 | CAS 1338247-30-5

Catalog number : 16071026

CAS number : 1338247-30-5

分子式 : C17H12Cl2F2N4OS 

分子量 : 429.2668 

Iupac 化学名称 : N-[5-[2-(2,6-Dichlorophenyl)-5-(difluoromethyl)pyrazol-3-yl]-1,3-thiazol-2-yl]cyclopropanecarboxamide 

Smile : ClC1=C(C(=CC=C1)Cl)N1N=C(C=C1C1=CN=C(S1)NC(=O)C1CC1)C(F)F

InChiKey : YBGGBHCJSAEIAS-UHFFFAOYSA-N

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同义词BMS-3; BMS 3 
英文同义词BMS-3; BMS 3 
分子式C17H12Cl2F2N4OS 
分子量429.2668 
外观Solid powder 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileClC1=C(C(=CC=C1)Cl)N1N=C(C=C1C1=CN=C(S1)NC(=O)C1CC1)C(F)F
InChiKeyYBGGBHCJSAEIAS-UHFFFAOYSA-N
InChiInChI=1S/C17H12Cl2F2N4OS/c18-9-2-1-3-10(19)14(9)25-12(6-11(24-25)15(20)21)13-7-22-17(27-13)23-16(26)8-4-5-8/h1-3,6-8,15H,4-5H2,(H,22,23,26)
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 BMS-3 is a LIM kinase 1 (LIMK1) inhibitor. LIMK inhibition with 1 M BMS-3 damaged MTOC protein localisation to spindle poles, undermined the formation and positioning of functional MTOC and thus disrupted spindle formation and chromosome alignment. These effects were phenocopied by microinjection of LIMK1 antibody into mouse oocytes. LIM kinase 1 (LIMK1) activity is essential for cell migration and cell cycle progression. 

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