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BLZ945

Catalog No.: 011314
Cas No.: 953769-46-5
Purity : 98% 
011314 - BLZ945 | CAS 953769-46-5

Catalog number : 011314

CAS number : 953769-46-5

分子式 : C20H22N4O3S 

分子量 : C20H22N4O3S 

Iupac 化学名称 : 4-((2-(((1R,2R)-2-hydroxycyclohexyl)amino)benzo[d]thiazol-6-yl)oxy)-N-methylpicolinamide 

Smile : O=C(NC)C1=NC=CC(OC2=CC3=C(N=C(N[C@@H]4CCCC[C@H]4O)S3)C=C2)=C1

InChiKey : ADZBMFGQQWPHMJ-RHSMWYFYSA-N

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同义词BLZ 945; BLZ-945 
英文同义词BLZ 945; BLZ-945 
分子式C20H22N4O3S 
分子量C20H22N4O3S 
外观Solid powder 
纯度98% 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileO=C(NC)C1=NC=CC(OC2=CC3=C(N=C(N[C@@H]4CCCC[C@H]4O)S3)C=C2)=C1
InChiKeyADZBMFGQQWPHMJ-RHSMWYFYSA-N
InChiInChI=1S/C20H22N4O3S/c1-21-19(26)16-10-13(8-9-22-16)27-12-6-7-15-18(11-12)28-20(24-15)23-14-4-2-3-5-17(14)25/h6-11,14,17,25H,2-5H2,1H3,(H,21,26)(H,23,24)/t14-,17-/m1/s1
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BLZ945 is a highly selective and brain-penetrant inhibitor of CSF1R with IC50 of 1 nM; >3200-fold higher than its affinity for other kinases. 

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