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BIX02188 编号 : 122205

化学信息

产品英文名称BIX02188
Iupac 化学名称(3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamide 
同义词BIX 02188; BIX-02188 
英文同义词BIX 02188; BIX-02188 
分子式C25H24N4O2 
分子量412.48 
SmileO=C(C3=CC(NC2=O)=C(C=C3)/C2=C(NC4=CC=CC(CN(C)C)=C4)\C1=CC=CC=C1)N
InChiKeyFSZPIAXLCCQFCM-FCQUAONHSA-N
InChiInChI=1S/C25H24N4O2/c1-29(2)15-16-7-6-10-19(13-16)27-23(17-8-4-3-5-9-17)22-20-12-11-18(24(26)30)14-21(20)28-25(22)31/h3-14,27H,15H2,1-2H3,(H2,26,30)(H,28,31)/b23-22-
Cas334949-59-6

技术数据

外观Solid powder 
纯度98% 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
质量控制

产品详情

BIX02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2. 

结构

122205 - BIX02188 | CAS 334949-59-6

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