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BH3I-1 编号 : 61402

化学信息

产品英文名称BH3I-1
Iupac 化学名称BH3I-1 
同义词BHI1; BHI-1; BHI 1; BH 3I1 
英文同义词BHI1; BHI-1; BHI 1; BH 3I1 
分子式C15H14BrNO3S2 
分子量400.31 
SmileCC(C)C(C(=O)O)N1C(=O)/C(=C\c2ccc(cc2)Br)/SC1=S
InChiKeyCOHIEJLWRGREHV-YRNVUSSQSA-N
InChiInChI=1S/C15H14BrNO3S2/c1-8(2)12(14(19)20)17-13(18)11(22-15(17)21)7-9-3-5-10(16)6-4-9/h3-8,12H,1-2H3,(H,19,20)/b11-7+
Cas300817-68-9
MDLMFCD03453544

技术数据

外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
质量控制

产品详情

BH3I-1 is an inhibitor of Bcl-xL with IC 50 of 293.95 M. BH3I-1 is a cell permeable BH3 mimetic that binds to Bcl-xL, BH3I-1 can induce cell death. BH3I-1 is a bak activator


BH3I-1 can exerted an antineoplastic effect in thyroid carcinoma cells and sensitized to sublethal concentrations of doxorubicin and bortezomib.
BH3I-1 had a strong sensitizing effect on bortezomib-induced cell death.


 

结构

61402 - BH3I-1 | CAS 300817-68-9

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