Shipped under ambient temperature as non-hazardous chemical.
BH3I-1 is an inhibitor of Bcl-xL with IC 50 of 293.95 M. BH3I-1 is a cell permeable BH3 mimetic that binds to Bcl-xL, BH3I-1 can induce cell death. BH3I-1 is a bak activator
BH3I-1 can exerted an antineoplastic effect in thyroid carcinoma cells and sensitized to sublethal concentrations of doxorubicin and bortezomib. BH3I-1 had a strong sensitizing effect on bortezomib-induced cell death.
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