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BAY1217389

Catalog No.: 16060801
Cas No.: 1554458-53-5
Purity : 98% by HPLC 
16060801 - BAY1217389 | CAS 1554458-53-5

Catalog number : 16060801

CAS number : 1554458-53-5

分子式 : C27H24F5N5O3 

分子量 : 561.513 

Iupac 化学名称 : N-cyclopropyl-4-(6-(2,3-difluoro-4-methoxyphenoxy)-8-((3,3,3-trifluoropropyl)amino)imidazo[1,2-b]pyridazin-3-yl)-2-methylbenzamide 

Smile : C1(CC1)NC(C1=C(C=C(C=C1)C1=CN=C2N1N=C(C=C2NCCC(F)(F)F)OC2=C(C(=C(C=C2)OC)F)F)C)=O

InChiKey : WNEILUNVMHVMPH-UHFFFAOYSA-N

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同义词BAY1217389; BAY-1217389 
英文同义词BAY1217389; BAY-1217389 
分子式C27H24F5N5O3 
分子量561.513 
外观Solid powder 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileC1(CC1)NC(C1=C(C=C(C=C1)C1=CN=C2N1N=C(C=C2NCCC(F)(F)F)OC2=C(C(=C(C=C2)OC)F)F)C)=O
InChiKeyWNEILUNVMHVMPH-UHFFFAOYSA-N
InChiInChI=1S/C27H24F5N5O3/c1-14-11-15(3-6-17(14)26(38)35-16-4-5-16)19-13-34-25-18(33-10-9-27(30,31)32)12-22(36-37(19)25)40-21-8-7-20(39-2)23(28)24(21)29/h3,6-8,11-13,16,33H,4-5,9-10H2,1-2H3,(H,35,38)
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BAY1217389 is an orally bioavailable, selective inhibitor of the serine/threonine kinase monopolar spindle 1 (Mps1, TTK), with potential antineoplastic activity. Upon administration, the Mps1 inhibitor BAY 1217389 selectively binds to and inhibits the activity of Mps1. This inactivates the spindle assembly checkpoint (SAC), accelerates mitosis, causes chromosomal misalignment and missegregation, and mitotic checkpoint complex destabilization. This induces cell death in Mps1-overexpressing cancer cells 

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