BAY-2416964
编号: 2091906
Cas号: 2242464-44-2
纯度: 98% Min.
BAY-2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1, example 192, has an IC50 of 341 nM. BAY2416964 specifically binds to AhR, inhibits AhR activation, and prevents AhR-mediated signaling. Abrogation of AhR activation prevents the activation of immune-tolerant dendritic cells (DCs) and regulatory T cells (Tregs) in the tumor microenvironment (TME). This may restore the immune response against tumor cells. .
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化学信息
| 名称 | BAY-2416964 |
|---|---|
| Iupac 化学名称 | (S)-6-(4-chlorophenyl)-N-(1-hydroxypropan-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)-3-oxo-2,3-dihydropyridazine-4-carboxamide |
| 同义词 | BAY-2416964; BAY 2416964; BAY2416964; |
| 英文同义词 | BAY-2416964; BAY 2416964; BAY2416964; |
| 分子式 | C18H18ClN5O3 |
| 分子量 | 387.824 |
| Smile | O=C(C1=CC(C2=CC=C(Cl)C=C2)=NN(C3=CN(C)N=C3)C1=O)N[C@@H](C)CO |
| InChiKey | YAGSZKAJPHGVOV-NSHDSACASA-N |
| InChi | InChI=1S/C18H18ClN5O3/c1-11(10-25)21-17(26)15-7-16(12-3-5-13(19)6-4-12)22-24(18(15)27)14-8-20-23(2)9-14/h3-9,11,25H,10H2,1-2H3,(H,21,26)/t11-/m0/s1 |
| Cas号 | 2242464-44-2 |
| 相关CAS号 |
订购信息
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