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BAM 7 编号 : 16071006

化学信息

产品英文名称BAM 7
Iupac 化学名称(E)-4-(2-(2-ethoxyphenyl)hydrazono)-5-methyl-2-(4-phenylthiazol-2-yl)-2,4-dihydro-3H-pyrazol-3-one 
同义词BAM 7; BAM-7 
英文同义词BAM 7; BAM-7 
分子式C21H19N5O2S 
分子量405.476 
SmileC(C)OC1=C(C=CC=C1)N\N=C/1\C(N(N=C1C)C=1SC=C(N1)C1=CC=CC=C1)=O
InChiKeyKOCVKGYKBLJEPK-LYBHJNIJSA-N
InChiInChI=1S/C21H19N5O2S/c1-3-28-18-12-8-7-11-16(18)23-24-19-14(2)25-26(20(19)27)21-22-17(13-29-21)15-9-5-4-6-10-15/h4-13,23H,3H2,1-2H3/b24-19+
Cas331244-89-4

技术数据

外观Solid powder 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
质量控制

产品详情

 BAM 7 is a Bax activator (EC50 = 3.3 M). BCL-2 family proteins are key regulators of the apoptotic pathway. Antiapoptotic members sequester the BCL-2 homology 3 (BH3) death domains of proapoptotic members such as BAX to maintain cell survival. The antiapoptotic BH3-binding groove has been successfully targeted to reactivate apoptosis in cancer. 

结构

16071006 - BAM 7 | CAS 331244-89-4

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