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Avitinib maleate

Catalog No.: 16122862
Cas No.: 1557268-88-8
Purity : 98% 
16122862 - Avitinib maleate | CAS 1557268-88-8

Catalog number : 16122862

CAS number : 1557268-88-8

分子式 : C30H30FN7O6 

分子量 : 603.6114 

Iupac 化学名称 : Avitinib maleate 

Smile : C(\C=C/C(=O)O)(=O)O.FC=1C=C(C=CC1N1CCN(CC1)C)NC=1N=C(C2=C(N1)NC=C2)OC=2C=C(C=CC2)NC(C=C)=O

InChiKey : VRHPZWLHPIENFW-BTJKTKAUSA-N

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同义词N/A 
英文同义词N/A 
分子式C30H30FN7O6 
分子量603.6114 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
SmileC(\C=C/C(=O)O)(=O)O.FC=1C=C(C=CC1N1CCN(CC1)C)NC=1N=C(C2=C(N1)NC=C2)OC=2C=C(C=CC2)NC(C=C)=O
InChiKeyVRHPZWLHPIENFW-BTJKTKAUSA-N
InChiInChI=1S/C26H26FN7O2.C4H4O4/c1-3-23(35)29-17-5-4-6-19(15-17)36-25-20-9-10-28-24(20)31-26(32-25)30-18-7-8-22(21(27)16-18)34-13-11-33(2)12-14-34;5-3(6)1-2-4(7)8/h3-10,15-16H,1,11-14H2,2H3,(H,29,35)(H2,28,30,31,32);1-2H,(H,5,6)(H,7,8)/b;2-1-
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Avitinib is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor, with potential antineoplastic activity. Upon oral administration, avitinib covalently binds to and inhibits the activity of mutant forms of EGFR, including the drug-resistant T790M EGFR mutant, which prevents signaling mediated by mutant forms of EGFR. This may both induce cell death and inhibit tumor growth in EGFR-mutated tumor cells. EGFR, a receptor tyrosine kinase that is mutated in a variety of cancers, plays a key role in tumor cell proliferation and tumor vascularization. As this agent is selective towards mutant forms of EGFR, its toxicity profile may be reduced when compared to non-selective EGFR inhibitors, which also inhibit wild-type EGFR. 

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