Arimoclomol citrate
Arimoclomol citrate is a heat shock protein amplifier potentially useful for the treatment of Niemann-Pick disease type C (NP-C). Arimoclomol is believed to function by stimulating a normal cellular protein repair pathway through the activation of molecular chaperones.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | Arimoclomol citrate |
|---|---|
| Iupac 化学名称 | 3-Pyridinecarboximidoyl chloride, N-((2R)-2-hydroxy-3-(1-piperidinyl)propoxy)-, 1-oxide, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) |
| 同义词 | Arimoclomol citrate; BRX-220; BRX 220; BRX220; BRX-345; BRX 345; BRX345; |
| 英文同义词 | Arimoclomol citrate; BRX-220; BRX 220; BRX220; BRX-345; BRX 345; BRX345; |
| 分子式 | C20H28ClN3O10 |
| 分子量 | 505.90 |
| Smile | O[C@@H](CON=C(Cl)c1ccc[n+]([O-])c1)CN2CCCCC2.OC(=O)CC(O)(CC(=O)O)C(=O)O |
| InChiKey | XSENLDLUMVYRET-BTQNPOSSSA-N |
| InChi | InChI=1S/C14H20ClN3O3.C6H8O7/c15-14(12-5-4-8-18(20)9-12)16-21-11-13(19)10-17-6-2-1-3-7-17;7-3(8)1-6(13,5(11)12)2-4(9)10/h4-5,8-9,13,19H,1-3,6-7,10-11H2;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/t13-;/m1./s1 |
| Cas号 | 368860-21-3 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | Off-white solid |
|---|---|
| 纯度 | 98% Min. |
| 存储 | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| 可溶性 | Soluble in DMSO |
| 处理方式 | |
| 运输条件 | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| 海关编码 |
| Targets | |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: McDermott CJ. Clinical trials in amyotrophic lateral sclerosis. Curr Opin Neurol. 2019 Oct;32(5):758-763. doi: 10.1097/WCO.0000000000000731. PubMed PMID: 31335338.
2: Hettinghouse A, Liu CJ. Brain-penetrant heat shock protein amplifier arimoclomol enhances GCase activity in in vitro Gaucher disease models. EBioMedicine. 2018 Dec;38:7-8. doi: 10.1016/j.ebiom.2018.11.052. Epub 2018 Dec 3. PubMed PMID: 30522930; PubMed Central PMCID: PMC6306393.
3: Fog CK, Zago P, Malini E, Solanko LM, Peruzzo P, Bornaes C, Magnoni R, Mehmedbasic A, Petersen NHT, Bembi B, Aerts JFMG, Dardis A, Kirkegaard T. The heat shock protein amplifier arimoclomol improves refolding, maturation and lysosomal activity of glucocerebrosidase. EBioMedicine. 2018 Dec;38:142-153. doi: 10.1016/j.ebiom.2018.11.037. Epub 2018 Nov 27. PubMed PMID: 30497978; PubMed Central PMCID: PMC6306395.
