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Apoptozole

Catalog No.: 161014002
Cas No.: 1054543-47-3
Purity : 98% by HPLC 
161014002 - Apoptozole | CAS 1054543-47-3

Catalog number : 161014002

CAS number : 1054543-47-3

分子式 : C33H24F6N3O3 

分子量 : 625.6 

化学名称 : Apoptozole

Smile : COc1ccc(cc1)c2c(n(c(n2)c3cc(cc(c3)C(F)(F)F)C(F)(F)F)Cc4ccc(cc4)C(=O)N)c5ccc(cc5)OC

InChiKey : ZIMMTPFXOMAJTQ-UHFFFAOYSA-N

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分子式C33H24F6N3O3 
分子量625.6 
外观Solid powder 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileCOc1ccc(cc1)c2c(n(c(n2)c3cc(cc(c3)C(F)(F)F)C(F)(F)F)Cc4ccc(cc4)C(=O)N)c5ccc(cc5)OC
InChiKeyZIMMTPFXOMAJTQ-UHFFFAOYSA-N
InChiInChI=1S/C33H25F6N3O3/c1-44-26-11-7-20(8-12-26)28-29(21-9-13-27(45-2)14-10-21)42(18-19-3-5-22(6-4-19)30(40)43)31(41-28)23-15-24(32(34,35)36)17-25(16-23)33(37,38)39/h3-17H,18H2,1-2H3,(H2,40,43)
MDLMFCD19443178
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Apoptosis Activator VII, Apoptozole is a cell-permeable imidazole compound that directly binds anti-apoptotic chaperone Hsc70 and its inducible homologue Hsp70 (Kd = 210 and 140 nM, respectively). Apoptozole is shown to effectively inhibit the proliferation of SK-OV-3, HCT-15, and A549 cancer cell lines (IC50 = 220, 250 and 130 nM, respectively) and induce 90% apoptotic cell death in P19 embryonic carcinoma and A549 lung cancer cultures after 12 hours drug treatment (1 M). 

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