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Apilimod mesylate ( STA-5326 )

编号: 23948
Cas号: 870087-36-8
纯度: ≧98.0%

Apilimod, also known as STA-5326, is a  potent IL-12/IL-23 inhibitor. Apilimod inhibits IL-12 and IL-23 production - cytokines that are involved in autoimmune diseases - through the prevention of nuclear translocation of c-Rel. Apilimod strongly inhibits IL-12 with IC50s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively.

仅供研究使用。 我们不向患者出售。

化学信息

名称Apilimod mesylate ( STA-5326 )
Iupac 化学名称(E)-4-(6-(2-(3-methylbenzylidene)hydrazinyl)-2-(2-(pyridin-2-yl)ethoxy)pyrimidin-4-yl)morpholine dimethanesulfonate
同义词Apilimod mesylate ; STA-5326 ; STA5326 ; STA 5326 ; LAM-002 ; LAM 002 ; LAM002 ;
英文同义词Apilimod mesylate ; STA-5326 ; STA5326 ; STA 5326 ; LAM-002 ; LAM 002 ; LAM002 ;
分子式C23H26N6O2
分子量418.49
SmileCC1=CC(/C=N/NC2=CC(N3CCOCC3)=NC(OCCC4=NC=CC=C4)=N2)=CC=C1
InChiKeyHSKAZIJJKRAJAV-KOEQRZSOSA-N
InChiInChI=1S/C23H26N6O2/c1-18-5-4-6-19(15-18)17-25-28-21-16-22(29-10-13-30-14-11-29)27-23(26-21)31-12-8-20-7-2-3-9-24-20/h2-7,9,15-17H,8,10-14H2,1H3,(H,26,27,28)/b25-17+
Cas号870087-36-8
相关CAS号870087-36-8 (mesylate) 541550-19-0 (free base)

订购信息

包装价格库存纯度备货期
大货询价询价询价
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外观性状类白色至白色固体
纯度≧98.0%
存储短期可在0-4度保存,数天至数月;长期可在-20度保存三年。
可溶性可溶于DMSO
处理方式
运输条件产品可以在室温下运输
海关编码
Coming soon.
TargetsIL-12/IL-23 inhibitor
MechanismApilimod is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 with IC50s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively.
Cell study
Animal study
Clinical study
Not available

化学结构

23948 - Apilimod mesylate ( STA-5326 ) | CAS 870087-36-8

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