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Ampkinone

Catalog No.: 611810
Cas No.: 1233082-79-5
Purity : 98% 
611810 - Ampkinone | CAS 1233082-79-5

Catalog number : 611810

CAS number : 1233082-79-5

分子式 : C31H23NO6 

分子量 : 505.52 

Iupac 化学名称 : Ampkinone 

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分子式C31H23NO6 
分子量505.52 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
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Ampkinone is a small molecule activator of AMPK; stimulate functional activation of AMPK via the phosphorylation at Thr172 in cultured L6 muscle cells with an EC50 value of 4.3 M, enhancing glucose uptake by 3.2-fold.


Ampkinone stimulated the phosphorylation of AMPK via the indirect activation of AMPK in various cell lines. Ampkinone-mediated activation of AMPK required the activity of LKB1 and resulted in increased glucose uptake in muscle cells. In addition, ampkinone-treated DIO mice significantly reduced total body weight and overall fat mass. Histological examination and measurement of lipid parameters showed that ampkinone effectively improved metabolic abnormalities in the DIO mice model.


 

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