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Alvelestat (AZD9688)

Catalog No.: 16122854
Cas No.: 848141-11-7
Purity : 98% 
16122854 - Alvelestat (AZD9688) | CAS 848141-11-7

Catalog number : 16122854

CAS number : 848141-11-7

分子式 : C25H22F3N5O4S 

分子量 : 545.53 

Iupac 化学名称 : 6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-((5-(methylsulfonyl)pyridin-2-yl)methyl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide

Smile : O=C(C1=CC(C2=CC=NN2C)=C(C)N(C3=CC=CC(C(F)(F)F)=C3)C1=O)NCC4=NC=C(S(=O)(C)=O)C=C4

InChiKey : QNQZWEGMKJBHEM-UHFFFAOYSA-N

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同义词ZD9668; AZD 9668; AZD-9668; MPH966; MPH 966; MPH-966; Alvelestat;
英文同义词ZD9668; AZD 9668; AZD-9668; MPH966; MPH 966; MPH-966; Alvelestat;
分子式C25H22F3N5O4S 
分子量545.53 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
SmileO=C(C1=CC(C2=CC=NN2C)=C(C)N(C3=CC=CC(C(F)(F)F)=C3)C1=O)NCC4=NC=C(S(=O)(C)=O)C=C4
InChiKeyQNQZWEGMKJBHEM-UHFFFAOYSA-N
InChiInChI=1S/C25H22F3N5O4S/c1-15-20(22-9-10-31-32(22)2)12-21(23(34)30-13-17-7-8-19(14-29-17)38(3,36)37)24(35)33(15)18-6-4-5-16(11-18)25(26,27)28/h4-12,14H,13H2,1-3H3,(H,30,34)
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Avelestat, also known as AZD9668, is a novel, oral inhibitor of neutrophil elastase (NE), an enzyme implicated in the signs, symptoms, and disease progression in NE-driven respiratory diseases such as bronchiectasis and chronic obstructive pulmonary disease via its role in the inflammatory process, mucus overproduction, and lung tissue damage. In cell-based assays, AZD9668 inhibited plasma NE activity in zymosan-stimulated whole blood. AZD9668 has the potential to reduce lung inflammation and the associated structural and functional changes in human diseases. 

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