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Alanosine

Catalog No.: 161227117
Cas No.: 5854-93-3
Purity : 98% 
161227117 - Alanosine | CAS 5854-93-3

Catalog number : 161227117

CAS number : 5854-93-3

分子式 : C3H7N3O4 

分子量 : 149.11 

Iupac 化学名称 : Alanosine 

Smile : N[C@@H](CN(O)N=O)C(=O)O

InChiKey : MLFKVJCWGUZWNV-REOHCLBHSA-N

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同义词SDX102; SDX-102; SDX 102; alanosine; L-alanosine 
英文同义词SDX102; SDX-102; SDX 102; alanosine; L-alanosine 
分子式C3H7N3O4 
分子量149.11 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
SmileN[C@@H](CN(O)N=O)C(=O)O
InChiKeyMLFKVJCWGUZWNV-REOHCLBHSA-N
InChiInChI=1S/C3H7N3O4/c4-2(3(7)8)1-6(10)5-9/h2,10H,1,4H2,(H,7,8)/t2-/m0/s1
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Alanosine, also known as L-alanosine, is an amino acid analogue and antibiotic derived from the bacterium Streptomyces alanosinicus with antimetabolite and potential antineoplastic activities. L-alanosine inhibits adenylosuccinate synthetase, which converts inosine monophospate (IMP) into adenylosuccinate, an intermediate in purine metabolism. L-alanosine-induced disruption of de novo purine biosynthesis is potentiated by methylthioadenosine phosphorylase (MTAP) deficiency. The clinical use of this agent may be limited by its toxicity profile. MTAP is a key enzyme in the adenine and methionine salvage pathways. 

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