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AkaLumine HCl

编号: 24134
Cas号: 2558205-28-8
纯度: 98% Min.

 AkaLumine is a luciferin analogue. The bioluminescence produced by AkaLumine in reactions with native firefly luciferase is in the near-infrared wavelength ranges (λmax=677 nm), and yields significantly increased target-detection sensitivity from deep tissues with maximal signals attained at very low concentrations, as compared with D-luciferin and emerging synthetic luciferin CycLuc1.

仅供研究使用。 我们不向患者出售。

化学信息

名称AkaLumine HCl
Iupac 化学名称(S)-2-((1E,3E)-4-(4-(dimethylamino)phenyl)buta-1,3-dien-1-yl)-4,5-dihydrothiazole-4-carboxylic acid hydrochloride
同义词AkaLumine hydrochloride; TokeOni; AkaLumine (hydrochloride); AkaLumine HCl
英文同义词AkaLumine hydrochloride; TokeOni; AkaLumine (hydrochloride); AkaLumine HCl
分子式C16H19ClN2O2S
分子量338.85
SmileCN(C1=CC=C(/C=C/C=C/C2=N[C@@H](C(O)=O)CS2)C=C1)C.Cl
InChiKeyPZCNKVAGZCXXHX-SSRSOBHISA-N
InChiInChI=1S/C16H18N2O2S.ClH/c1-18(2)13-9-7-12(8-10-13)5-3-4-6-15-17-14(11-21-15)16(19)20;/h3-10,14H,11H2,1-2H3,(H,19,20);1H/b5-3+,6-4+;/t14-;/m1./s1
Cas号2558205-28-8
相关CAS号

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包装价格库存纯度备货期
大货询价询价询价
Request Bulk Quote Download MSDS 电话 : +86-177 0271 9238   Email : sales@sun-shinechem.com
外观性状Off-white solid
纯度98% Min.
存储Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).
可溶性Soluble in DMSO
处理方式
运输条件Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
海关编码
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1: Su Y, Walker JR, Park Y, Smith TP, Liu LX, Hall MP, Labanieh L, Hurst R, Wang DC, Encell LP, Kim N, Zhang F, Kay MA, Casey KM, Majzner RG, Cochran JR, Mackall CL, Kirkland TA, Lin MZ. Novel NanoLuc substrates enable bright two-population bioluminescence imaging in animals. Nat Methods. 2020 Aug;17(8):852-860. doi: 10.1038/s41592-020-0889-6. Epub 2020 Jul 13. PMID: 32661427.


2: Ogawa H, Ono R, Noguchi Y, Kitada N, Saito-Moriya R, Maki SA, Akiyama H, Itabashi H, Hiyama M. Absorption Spectra for Firefly Bioluminescence Substrate Analog: TokeOni in Various pH Solutions. Photochem Photobiol. 2021 Sep;97(5):1016-1022. doi: 10.1111/php.13458. Epub 2021 Jun 21. PMID: 34081790.


3: Hendrickx S, Bulté D, Mabille D, Mols R, Claes M, Ilbeigi K, Ahmad R, Dirkx L, Van Acker SI, Caljon G. Comparison of Bioluminescent Substrates in Natural Infection Models of Neglected Parasitic Diseases. Int J Mol Sci. 2022 Dec 16;23(24):16074. doi: 10.3390/ijms232416074. PMID: 36555716; PMCID: PMC9781651.


4: Su Y, Walker JR, Hall MP, Klein MA, Wu X, Encell LP, Casey KM, Liu LX, Hong G, Lin MZ, Kirkland TA. An optimized bioluminescent substrate for non-invasive imaging in the brain. Nat Chem Biol. 2023 Jun;19(6):731-739. doi: 10.1038/s41589-023-01265-x. Epub 2023 Feb 9. PMID: 36759751; PMCID: PMC10229426.


5: Kuchimaru T, Iwano S, Kiyama M, Mitsumata S, Kadonosono T, Niwa H, Maki S, Kizaka-Kondoh S. A luciferin analogue generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging. Nat Commun. 2016 Jun 14;7:11856. doi: 10.1038/ncomms11856. PMID: 27297211; PMCID: PMC4911627.


6: Lim W, Kim B, Jo G, Yang DH, Park MH, Hyun H. Bioluminescence and near- infrared fluorescence imaging for detection of metastatic bone tumors. Lasers Med Sci. 2020 Feb;35(1):115-120. doi: 10.1007/s10103-019-02801-9. Epub 2019 Jun 1. PMID: 31154597.


7: Nakayama J, Saito R, Hayashi Y, Kitada N, Tamaki S, Han Y, Semba K, Maki SA. High Sensitivity In Vivo Imaging of Cancer Metastasis Using a Near-Infrared Luciferin Analogue seMpai. Int J Mol Sci. 2020 Oct 24;21(21):7896. doi: 10.3390/ijms21217896. PMID: 33114327; PMCID: PMC7660630.


8: Zambito G, Gaspar N, Ridwan Y, Hall MP, Shi C, Kirkland TA, Encell LP, Löwik C, Mezzanotte L. Evaluating Brightness and Spectral Properties of Click Beetle and Firefly Luciferases Using Luciferin Analogues: Identification of Preferred Pairings of Luciferase and Substrate for In Vivo Bioluminescence Imaging. Mol Imaging Biol. 2020 Dec;22(6):1523-1531. doi: 10.1007/s11307-020-01523-7. Epub 2020 Sep 14. PMID: 32926287; PMCID: PMC7666294.


9: Zhong C, Kayamori K, Koide S, Shinoda D, Oshima M, Nakajima-Takagi Y, Nagai Y, Mimura N, Sakaida E, Yamazaki S, Iwano S, Miyawaki A, Ito R, Tohyama K, Yamaguchi K, Furukawa Y, Lennox W, Sheedy J, Weetall M, Iwama A. Efficacy of the novel tubulin polymerization inhibitor PTC-028 for myelodysplastic syndrome. Cancer Sci. 2020 Dec;111(12):4336-4347. doi: 10.1111/cas.14684. Epub 2020 Nov 2. PMID: 33037737; PMCID: PMC7734154.


10: Yeh HW, Xiong Y, Wu T, Chen M, Ji A, Li X, Ai HW. ATP-Independent Bioluminescent Reporter Variants To Improve in Vivo Imaging. ACS Chem Biol. 2019 May 17;14(5):959-965. doi: 10.1021/acschembio.9b00150. Epub 2019 Apr 17. PMID: 30969754; PMCID: PMC6528180.


11: Gaspar N, Walker JR, Zambito G, Marella-Panth K, Lowik C, Kirkland TA, Mezzanotte L. Evaluation of NanoLuc substrates for bioluminescence imaging of transferred cells in mice. J Photochem Photobiol B. 2021 Mar;216:112128. doi: 10.1016/j.jphotobiol.2021.112128. Epub 2021 Jan 26. PMID: 33529963.


12: Viviani VR, Bevilaqua VR, de Souza DR, Pelentir GF, Kakiuchi M, Hirano T. A Very Bright Far-Red Bioluminescence Emitting Combination Based on Engineered Railroad Worm Luciferase and 6'-Amino-Analogs for Bioimaging Purposes. Int J Mol Sci. 2020 Dec 30;22(1):303. doi: 10.3390/ijms22010303. PMID: 33396708; PMCID: PMC7794784.

化学结构

24134 - AkaLumine HCl | CAS 2558205-28-8

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