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Afuresertib HCl

Catalog No.: 161227116
Cas No.: 1047645-82-8
Purity : 98% 
161227116 - Afuresertib HCl | CAS 1047645-82-8

Catalog number : 161227116

CAS number : 1047645-82-8

分子式 : C18H18Cl3FN4OS 

分子量 : 463.78 

Iupac 化学名称 : Afuresertib HCl 

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同义词GSK2110183; GSK 2110183; GSK-2110183; GSK2110183B; GSK 2110183B; GSK2110183B; Afuresertib 
英文同义词GSK2110183; GSK 2110183; GSK-2110183; GSK2110183B; GSK 2110183B; GSK2110183B; Afuresertib 
分子式C18H18Cl3FN4OS 
分子量463.78 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
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Afuresertib, also known as GSK2110183, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor GSK2110183 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents. 

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