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AZD5363

Catalog No.: 71805
Cas No.: 1143532-39-1
Purity : 98% by HPLC 
71805 - AZD5363 | CAS 1143532-39-1

Catalog number : 71805

CAS number : 1143532-39-1

分子式 : C21H25ClN6O2 

分子量 : 428.92 

Iupac 化学名称 : 4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinecarboxamide 

Smile : O=C(C1(N)CCN(C2=C3C(NC=C3)=NC=N2)CC1)N[C@H](C4=CC=C(Cl)C=C4)CCO

InChiKey : JDUBGYFRJFOXQC-KRWDZBQOSA-N

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同义词AZD 5363,AZD-5363 
英文同义词AZD 5363,AZD-5363 
分子式C21H25ClN6O2 
分子量428.92 
外观crystalline solid 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 6 months-80ºCin solvent 
运输条件Shipped under ambient temperature 
SmileO=C(C1(N)CCN(C2=C3C(NC=C3)=NC=N2)CC1)N[C@H](C4=CC=C(Cl)C=C4)CCO
InChiKeyJDUBGYFRJFOXQC-KRWDZBQOSA-N
InChiInChI=1S/C21H25ClN6O2/c22-15-3-1-14(2-4-15)17(6-12-29)27-20(30)21(23)7-10-28(11-8-21)19-16-5-9-24-18(16)25-13-26-19/h1-5,9,13,17,29H,6-8,10-12,23H2,(H,27,30)(H,24,25,26)/t17-/m0/s1
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AZD5363 is a  novel pyrrolopyrimidine derivative, and an orally available inhibitor of the serine/threonine protein kinase AKT (protein kinase B) with potential antineoplastic activity. AKT inhibitor AZD5363 binds to and inhibits all AKT isoforms. Inhibition of AKT prevents the phosphorylation of AKT substrates that mediate cellular processes, such as cell division, apoptosis, and glucose and fatty acid metabolism. A wide range of solid and hematological malignancies show dysregulated PI3K/AKT/mTOR signaling due to mutations in multiple signaling components. By targeting AKT, the key node in the PIK3/AKT signaling network, this agent may be used as monotherapy or combination therapy for a variety of human cancers. Check for active clinical trials using this agent. (NCI Thesaurus)

 

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