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AZD3759

Catalog No.: 901301
Cas No.: 1626387-80-1
Purity : 99% by HPLC 
901301 - AZD3759 | CAS 1626387-80-1

Catalog number : 901301

CAS number : 1626387-80-1

分子式 : C22H23ClFN5O3 

分子量 : 459.90 

Iupac 化学名称 : (R)-4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl 2,4-dimethylpiperazine-1-carboxylate 

Smile : COC1=C(OC(N2[C@H](C)CN(C)CC2)=O)C=C3C(N=CN=C3NC4=CC=CC(Cl)=C4F)=C1

InChiKey : MXDSJQHFFDGFDK-CYBMUJFWSA-N

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同义词AZD-3759;AZD3759;AZD 3759 
英文同义词AZD-3759;AZD3759;AZD 3759 
分子式C22H23ClFN5O3 
分子量459.90 
外观off-white solid 
纯度99% by HPLC 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 6 months-80ºCin solvent 
运输条件Shipped under ambient temperature 
SmileCOC1=C(OC(N2[C@H](C)CN(C)CC2)=O)C=C3C(N=CN=C3NC4=CC=CC(Cl)=C4F)=C1
InChiKeyMXDSJQHFFDGFDK-CYBMUJFWSA-N
InChiInChI=1S/C22H23ClFN5O3/c1-13-11-28(2)7-8-29(13)22(30)32-19-9-14-17(10-18(19)31-3)25-12-26-21(14)27-16-6-4-5-15(23)20(16)24/h4-6,9-10,12-13H,7-8,11H2,1-3H3,(H,25,26,27)/t13-/m1/s1
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AZD3759 is an orally available inhibitor of the epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Upon oral administration, AZD3759 binds to and inhibits the activity of EGFR as well as certain mutant forms of EGFR. This prevents EGFR-mediated signaling, and may lead to both induction of cell death and inhibition of tumor growth in EGFR-overexpressing cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization. Check for active clinical trials using this agent. (NCI Thesaurus)

 

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