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AZD2281(Olaparib)

Catalog No.: 92801
Cas No.: 763113-22-0
Purity : 98% by HPLC 
92801 - AZD2281(Olaparib) | CAS 763113-22-0

Catalog number : 92801

CAS number : 763113-22-0

分子式 : C24H23FN4O3 

分子量 : 434.46 

Iupac 化学名称 : 1-(Cyclopropylcarbonyl)-4-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]piperazine 

Smile : O=C(N1CCN(C(C2CC2)=O)CC1)C3=CC(CC4=NNC(C5=C4C=CC=C5)=O)=CC=C3F

InChiKey : FDLYAMZZIXQODN-UHFFFAOYSA-N

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同义词AZD-2281;AZD 2281 
英文同义词AZD-2281;AZD 2281 
分子式C24H23FN4O3 
分子量434.46 
外观off-white solid 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 6 months-80ºCin solvent 
运输条件Shipped under ambient temperature 
SmileO=C(N1CCN(C(C2CC2)=O)CC1)C3=CC(CC4=NNC(C5=C4C=CC=C5)=O)=CC=C3F
InChiKeyFDLYAMZZIXQODN-UHFFFAOYSA-N
InChiInChI=1S/C24H23FN4O3/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26-21)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16/h1-5,8,13,16H,6-7,9-12,14H2,(H,27,30)
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Olaparib (AZD-2281, trade name Lynparza) is an FDA-approved targeted therapy for cancer, developed by KuDOS Pharmaceuticals and later by AstraZeneca. It is a PARP inhibitor, inhibiting poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair.It acts against cancers in people with hereditary BRCA1 or BRCA2 mutations, which include some ovarian, breast, and prostate cancers. In December 2014, olaparib was approved for use as a single agent by the EMA and the FDA. The FDA approval is in for germline BRCA mutated (gBRCAm) advanced ovarian cancer that has received three or more prior lines of chemotherapy.

 

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