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Catalog No.: 16122864
Cas No.: 878385-84-3
Purity : 98% 
16122864 - AZD-5069 | CAS 878385-84-3

Catalog number : 16122864

CAS number : 878385-84-3

分子式 : C18H22F2N4O5S2 

分子量 : 476.51 

Iupac 化学名称 : AZD-5069 

InChiKey :

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同义词AZD 5069; AZD5069 
英文同义词AZD 5069; AZD5069 
外观crystalline solid 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
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AZD-5069 is a potent and selective CXCR2 antagonist with the potential to inhibit neutrophil migration into the airways in patients with COPD. AZD-5069 was shown to inhibit binding of radiolabeled CXCL8 to human CXCR2 with a pIC50 value of 9.1. Furthermore, AZD5069 inhibited neutrophil chemotaxis, with a pA2 of approximately 9.6, and adhesion molecule expression, with a pA2 of 6.9, in response to CXCL1. AZD5069 was a slowly reversible antagonist of CXCR2 with effects of time and temperature evident on the pharmacology and binding kinetics. AZD-5069 is also potential useful for patient in inflammatory conditions. 

878385-84-3 - Request Bulk Quote

878385-84-3 - Request Bulk Quote