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AVN944

Catalog No.: 022201
Cas No.: 297730-17-7
Purity : 98% 

AVN944 is an orally available, synthetic small molecule with potential antineoplastic activity, which inhibits inosine monosphosphate dehydrogenase (IMPDH), an enzyme involved in the de novo synthesis of guanosine triphosphate (GTP), a purine molecule required for DNA and RNA synthesis. Inhibition of IMPDH deprives cancer cells of GTP, resulting in disruption of DNA and RNA synthesis, inhibition of cell proliferation, and the induction of apoptosis. 

For research use only. We do not sell to patients.

Chemical Information

名称AVN944
Iupac 化学名称[(2R)-1-cyanobutan-2-yl] N-[(1S)-1-[3-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamoylamino]phenyl]ethyl]carbamate 
同义词AVN-944; AVN 944; VX944; VX 944; VX-944 
英文同义词AVN-944; AVN 944; VX944; VX 944; VX-944 
分子式C25H27N5O5 
分子量477.512 
SmileO=C(O[C@H](CC)CC#N)N[C@H](C1=CC=CC(NC(NC2=CC=C(C3=CN=CO3)C(OC)=C2)=O)=C1)C
InChiKeyGYCPCOJTCINIFZ-OXJNMPFZSA-N
InChiInChI=1S/C25H27N5O5/c1-4-20(10-11-26)35-25(32)28-16(2)17-6-5-7-18(12-17)29-24(31)30-19-8-9-21(22(13-19)33-3)23-14-27-15-34-23/h5-9,12-16,20H,4,10H2,1-3H3,(H,28,32)(H2,29,30,31)/t16-,20+/m0/s1
Cas号297730-17-7
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Ordering Information

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FormulationSolid powder 
纯度98% 
存储-20 ºC for 3 years 
可溶性Soluble in DMSO 
Handling
运输条件Shipped under ambient temperature 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

022201 - AVN944 | CAS 297730-17-7

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