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AVN944

编号: 022201
Cas号: 297730-17-7
纯度: 98% 

AVN944 is an orally available, synthetic small molecule with potential antineoplastic activity, which inhibits inosine monosphosphate dehydrogenase (IMPDH), an enzyme involved in the de novo synthesis of guanosine triphosphate (GTP), a purine molecule required for DNA and RNA synthesis. Inhibition of IMPDH deprives cancer cells of GTP, resulting in disruption of DNA and RNA synthesis, inhibition of cell proliferation, and the induction of apoptosis. 

仅供研究使用。 我们不向患者出售。

化学信息

名称AVN944
Iupac 化学名称[(2R)-1-cyanobutan-2-yl] N-[(1S)-1-[3-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamoylamino]phenyl]ethyl]carbamate 
同义词AVN-944; AVN 944; VX944; VX 944; VX-944 
英文同义词AVN-944; AVN 944; VX944; VX 944; VX-944 
分子式C25H27N5O5 
分子量477.512 
SmileO=C(O[C@H](CC)CC#N)N[C@H](C1=CC=CC(NC(NC2=CC=C(C3=CN=CO3)C(OC)=C2)=O)=C1)C
InChiKeyGYCPCOJTCINIFZ-OXJNMPFZSA-N
InChiInChI=1S/C25H27N5O5/c1-4-20(10-11-26)35-25(32)28-16(2)17-6-5-7-18(12-17)29-24(31)30-19-8-9-21(22(13-19)33-3)23-14-27-15-34-23/h5-9,12-16,20H,4,10H2,1-3H3,(H,28,32)(H2,29,30,31)/t16-,20+/m0/s1
Cas号297730-17-7
相关CAS号

订购信息

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外观性状Solid powder 
纯度98% 
存储-20 ºC for 3 years 
可溶性Soluble in DMSO 
处理方式
运输条件Shipped under ambient temperature 
海关编码
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

化学结构

022201 - AVN944 | CAS 297730-17-7

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