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AVN944

Catalog No.: 022201
Cas No.: 297730-17-7
Purity : 98% 
022201 - AVN944 | CAS 297730-17-7

Catalog number : 022201

CAS number : 297730-17-7

分子式 : C25H27N5O5 

分子量 : 477.512 

Iupac 化学名称 : [(2R)-1-cyanobutan-2-yl] N-[(1S)-1-[3-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamoylamino]phenyl]ethyl]carbamate 

Smile : O=C(O[C@H](CC)CC#N)N[C@H](C1=CC=CC(NC(NC2=CC=C(C3=CN=CO3)C(OC)=C2)=O)=C1)C

InChiKey : GYCPCOJTCINIFZ-OXJNMPFZSA-N

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同义词AVN-944; AVN 944; VX944; VX 944; VX-944 
英文同义词AVN-944; AVN 944; VX944; VX 944; VX-944 
分子式C25H27N5O5 
分子量477.512 
外观Solid powder 
纯度98% 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileO=C(O[C@H](CC)CC#N)N[C@H](C1=CC=CC(NC(NC2=CC=C(C3=CN=CO3)C(OC)=C2)=O)=C1)C
InChiKeyGYCPCOJTCINIFZ-OXJNMPFZSA-N
InChiInChI=1S/C25H27N5O5/c1-4-20(10-11-26)35-25(32)28-16(2)17-6-5-7-18(12-17)29-24(31)30-19-8-9-21(22(13-19)33-3)23-14-27-15-34-23/h5-9,12-16,20H,4,10H2,1-3H3,(H,28,32)(H2,29,30,31)/t16-,20+/m0/s1
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AVN944 is an orally available, synthetic small molecule with potential antineoplastic activity, which inhibits inosine monosphosphate dehydrogenase (IMPDH), an enzyme involved in the de novo synthesis of guanosine triphosphate (GTP), a purine molecule required for DNA and RNA synthesis. Inhibition of IMPDH deprives cancer cells of GTP, resulting in disruption of DNA and RNA synthesis, inhibition of cell proliferation, and the induction of apoptosis. 

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