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AMG232

Catalog No.: 011911
Cas No.: 1352066-68-2
Purity : 98% 
011911 - AMG232 | CAS 1352066-68-2

Catalog number : 011911

CAS number : 1352066-68-2

分子式 : C28H35Cl2NO5S 

分子量 : 568.55 

Iupac 化学名称 : 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid 

Smile : CC(C)S(C[C@H](C(C)C)N(C1=O)[C@@H]([C@H](C[C@@]1(CC(O)=O)C)C2=CC=CC(Cl)=C2)C3=CC=C(C=C3)Cl)(=O)=O

InChiKey : DRLCSJFKKILATL-YWCVFVGNSA-N

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同义词AMG-232; AMG 232 
英文同义词AMG-232; AMG 232 
分子式C28H35Cl2NO5S 
分子量568.55 
外观Solid powder 
纯度98% 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileCC(C)S(C[C@H](C(C)C)N(C1=O)[C@@H]([C@H](C[C@@]1(CC(O)=O)C)C2=CC=CC(Cl)=C2)C3=CC=C(C=C3)Cl)(=O)=O
InChiKeyDRLCSJFKKILATL-YWCVFVGNSA-N
InChiInChI=1S/C28H35Cl2NO5S/c1-17(2)24(16-37(35,36)18(3)4)31-26(19-9-11-21(29)12-10-19)23(20-7-6-8-22(30)13-20)14-28(5,27(31)34)15-25(32)33/h6-13,17-18,23-24,26H,14-16H2,1-5H3,(H,32,33)/t23-,24-,26-,28-/m1/s1
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AMG232 is an extremely potent MDM2 inhibitor (SPR KD = 0.045 nM, SJSA-1 EdU IC50 = 9.1 nM), with remarkable pharmacokinetic properties and in vivo antitumor activity in the SJSA-1 osteosarcoma xenograft model.
 

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