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AMG-510

编号: 112193
Cas号: 2296729-00-3
纯度: 98% Min.

AMG-510 is a potent KRAS G12C covalent inhibitor. AMG-510 selectively targets the KRAS p.G12C mutant, at either the DNA, RNA or protein level, and prevents, through an as of yet not elucidated manner, expression of and/or tumor cell signaling through the KRAS p.G12C mutant. This may inhibit growth in KRAS p.G12C-expressing tumor cells.

仅供研究使用。 我们不向患者出售。

化学信息

名称AMG-510
Iupac 化学名称Pyrido[2,3-d]pyrimidin-2(1H)-one, 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-, (1R)-
同义词AMG 510 ; AMG-510 ; AMG510
英文同义词AMG 510 ; AMG-510 ; AMG510
分子式C30H30F2N6O3
分子量560.59
SmileC(C=C)(=O)N1CC(N(CC1)C=1C2=C(N(C(N1)=O)C=1C(=NC=CC1C)C(C)C)N=C(C(=C2)F)C2=C(C=CC=C2O)F)C
InChiKeyNXQKSXLFSAEQCZ-UHFFFAOYSA-N
InChiInChI=1S/C30H30F2N6O3/c1-6-23(40)36-12-13-37(18(5)15-36)28-19-14-21(32)26(24-20(31)8-7-9-22(24)39)34-29(19)38(30(41)35-28)27-17(4)10-11-33-25(27)16(2)3/h6-11,14,16,18,39H,1,12-13,15H2,2-5H3
Cas号2296729-00-3
相关CAS号2252403-56-6 ( AMG-510 racemate ) ; 2296729-00-3 ( AMG510 )

订购信息

包装价格库存纯度备货期
大货询价询价询价
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外观性状crystalline solid 
纯度98% Min.
存储短期可在0-4度保存,数天至数月;长期可在-20度保存三年。
可溶性可溶于DMSO;不溶于水
处理方式Avoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.
运输条件可在常温下运输
海关编码
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

化学结构

112193 - AMG-510 | CAS 2296729-00-3

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