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AM-580

Catalog No.: 16062701
Cas No.: 102121-60-8
Purity : 98% by HPLC 
16062701 - AM-580 | CAS 102121-60-8

Catalog number : 16062701

CAS number : 102121-60-8

分子式 : C22H25NO3 

分子量 : 351.446 

Iupac 化学名称 : 4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene-2-carboxamido)benzoic acid 

Smile : CC1(C=2C=CC(=CC2C(CC1)(C)C)C(=O)NC1=CC=C(C(=O)O)C=C1)C

InChiKey : SZWKGOZKRMMLAJ-UHFFFAOYSA-N

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同义词AM-580; AM 580 
英文同义词AM-580; AM 580 
分子式C22H25NO3 
分子量351.446 
外观Solid powder 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileCC1(C=2C=CC(=CC2C(CC1)(C)C)C(=O)NC1=CC=C(C(=O)O)C=C1)C
InChiKeySZWKGOZKRMMLAJ-UHFFFAOYSA-N
InChiInChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-15(7-10-17(18)21)19(24)23-16-8-5-14(6-9-16)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26)
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AM-580 is a potent RARalpha agonist. AM580 has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells. AM580 inhibited the wnt pathway, measured by loss of nuclear beta-catenin, suggesting partial oncogene dependence of therapy. Am580 treatment increased RARbeta and lowered the level of RARgamma, an isotype whose expression we linked with tumor proliferation. Specific activation of a single retinoic acid receptor-alpha (RARalpha), without direct and concurrent activation of RARbeta and gamma, will inhibit mammary tumor oncogenesis in murine models relevant to human cancer. 

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