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AM-2394

Catalog No.: 16122855
Cas No.: 1442684-77-6
Purity : 98% 
16122855 - AM-2394 | CAS 1442684-77-6

Catalog number : 16122855

CAS number : 1442684-77-6

分子式 : C22H25N5O4 

分子量 : 423.473 

Iupac 化学名称 : AM-2394 

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同义词AM 2394; AM2394 
英文同义词AM 2394; AM2394 
分子式C22H25N5O4 
分子量423.473 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
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AM-2394 is a potent and selective Glucokinase agonist (GKA), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394 activates GK with an EC50 of 60 nM, increases the affinity of GK for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes. 

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