AG-7404
AG-7404 is a potent protease inhibitor with Anti-poliovirus activity. AG-7404 was active against all virus with EC50 values ranging from 0.080 to 0.674 μM. AG-7404 was fully active against all V-073-resistant variants, with EC₅₀ values ranging from 0.218 to 0.819 μM, compared to values of 0.202-0.407 μM for the V-073-susceptible parental strains. In vitro drug combination experiments demonstrated synergy between AG-7404 and either V-073 or BTA798, whereas the combination of the two capsid inhibitors acted additively.
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化学信息
| 名称 | AG-7404 |
|---|---|
| Iupac 化学名称 | (S,E)-ethyl 4-((S)-2-(3-(5-methylisoxazole-3-carboxamido)-2-oxopyridin-1(2H)-yl)pent-4-ynamido)-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoate |
| 同义词 | AG-7404; AG 7404; AG7404; V 7404; V-7404; V7404; |
| 英文同义词 | AG-7404; AG 7404; AG7404; V 7404; V-7404; V7404; |
| 分子式 | C26H29N5O7 |
| 分子量 | 523.54 |
| Smile | O=C(OCC)/C=C/[C@@H](NC([C@@H](N1C=CC=C(NC(C2=NOC(C)=C2)=O)C1=O)CC#C)=O)C[C@H]3C(NCC3)=O |
| InChiKey | QCUZOJBYWQPLIN-BNMFZAHFSA-N |
| InChi | InChI=1S/C26H29N5O7/c1-4-7-21(31-13-6-8-19(26(31)36)29-24(34)20-14-16(3)38-30-20)25(35)28-18(9-10-22(32)37-5-2)15-17-11-12-27-23(17)33/h1,6,8-10,13-14,17-18,21H,5,7,11-12,15H2,2-3H3,(H,27,33)(H,28,35)(H,29,34)/b10-9+/t17-,18+,21-/m0/s1 |
| Cas号 | 343565-99-1 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | 固体粉末 |
|---|---|
| 纯度 | 98% Min. |
| 存储 | 短期（几天到几周）为0-4摄氏度，长期（几个月）为-20摄氏度 |
| 可溶性 | 溶于DMSO |
| 处理方式 | |
| 运输条件 | 作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周. |
| 海关编码 |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Rhoden E, Liu HM, Wang-Chern SW, Oberste MS. Anti-poliovirus activity of protease inhibitor AG-7404, and assessment of in vitro activity in combination
with antiviral capsid inhibitor compounds. Antiviral Res. 2013 May;98(2):186-91. doi: 10.1016/j.antiviral.2013.03.003. Epub 2013 Mar 13. Erratum in: Antiviral Res. 2013 Sep;99(3):436. PubMed PMID: 23499651.
