ACY-775 is a potent and selective HDAC6 inhbiitor. ACY-775 inhibits HDAC6 with low nanomolar potency and a selectivity of 60- to 1500-fold over class I HDACs. ACY-775 shares the antidepressant-like properties of other HDAC inhibitors, such as SAHA and MS-275, in the tail suspension test and social defeat paradigm
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名称 | ACY-775 |
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Iupac 化学名称 | 2-((1-(3-Fluorophenyl)cyclohexyl)amino)-n-hydroxypyrimidine-5-carboxamide |
同义词 | ACY-775;ACY775;ACY 775 |
英文同义词 | ACY-775;ACY775;ACY 775 |
分子式 | C17H19FN4O2 |
分子量 | 330.36 |
Smile | FC=1C=C(C=CC1)C1(CCCCC1)NC1=NC=C(C=N1)C(=O)NO |
InChiKey | IYBURCQQEUNLDL-UHFFFAOYSA-N |
InChi | InChI=1S/C17H19FN4O2/c18-14-6-4-5-13(9-14)17(7-2-1-3-8-17)21-16-19-10-12(11-20-16)15(23)22-24/h4-6,9-11,24H,1-3,7-8H2,(H,22,23)(H,19,20,21) |
Cas号 | 1375466-18-4 |
相关CAS号 |
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