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AC-90179 HCl

编号: 23178
Cas号: 359878-19-6
纯度: 98% Min.

AC-90179 is a high selective 5-hydroxytryptamine2A receptor inverse agonist. It is an atypical antipsychotic pharmaceutical. It has been shown to alleviate hallucinogen-induced vasocontriction and possible other harmful physical symptoms.

仅供研究使用。 我们不向患者出售。

化学信息

名称AC-90179 HCl
Iupac 化学名称2-(4-Methoxyphenyl)-n-[(4-methylphenyl)methyl]-n-(1-methylpiperidin-4-yl)acetamide hydrochloride
同义词AC-90179; AC 90179; AC90179; AC-90179 HCl; AC-90179 hydrochloride
英文同义词AC-90179; AC 90179; AC90179; AC-90179 HCl; AC-90179 hydrochloride
分子式C23H31ClN2O2
分子量402.96
SmileCl.COC1=CC=C(C=C1)CC(=O)N(C1CCN(CC1)C)CC1=CC=C(C=C1)C
InChiKeyJFSJPTRVYLBFQC-UHFFFAOYSA-N
InChiInChI=1S/C23H30N2O2.ClH/c1-18-4-6-20(7-5-18)17-25(21-12-14-24(2)15-13-21)23(26)16-19-8-10-22(27-3)11-9-19;/h4-11,21H,12-17H2,1-3H3;1H
Cas号359878-19-6
相关CAS号

订购信息

包装价格库存纯度备货期
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外观性状 类白色至白色固体
纯度98% Min.
存储短期可在0-4度保存,数天至数月;长期可在-20度保存三年。
可溶性可溶于DMSO;不溶于水
处理方式
运输条件可在常温下运输
海关编码
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1: Vanover KE, Harvey SC, Son T, Bradley SR, Kold H, Makhay M, Veinbergs I, Spalding TA, Weiner DM, Andersson CM, Tolf BR, Brann MR, Hacksell U, Davis RE. Pharmacological characterization of AC-90179 [2-(4-methoxyphenyl)-N-(4-methyl-benzyl)-N-(1-methyl-piperidin-4-yl)-acetamide hydrochloride]: a selective serotonin 2A receptor inverse agonist. J Pharmacol Exp Ther. 2004 Sep;310(3):943-51. Epub 2004 Apr 21. PubMed PMID: 15102927.

2: Ruderman MA, Powell SB, Geyer MA. A Kappa Opioid Model of Atypical Altered Consciousness and Psychosis: U50488, DOI, AC90179 Effects on Prepulse Inhibition and Locomotion in Mice. J Young Investig. 2009 Jul 1;19(13):1-7. PubMed PMID: 25346645; PubMed Central PMCID: PMC4208663.

3: Blessing WW, Seaman B. 5-hydroxytryptamine(2A) receptors regulate sympathetic nerves constricting the cutaneous vascular bed in rabbits and rats. Neuroscience. 2003;117(4):939-48. PubMed PMID: 12654345.

4: Weiner DM, Burstein ES, Nash N, Croston GE, Currier EA, Vanover KE, Harvey SC, Donohue E, Hansen HC, Andersson CM, Spalding TA, Gibson DF, Krebs-Thomson K, Powell SB, Geyer MA, Hacksell U, Brann MR. 5-hydroxytryptamine2A receptor inverse agonists as antipsychotics. J Pharmacol Exp Ther. 2001 Oct;299(1):268-76. PubMed PMID: 11561089.


化学结构

23178 - AC-90179 HCl | CAS 359878-19-6

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