ABX-1431
ABX-1431 is a covalent, irreversible MGLL inhibitor. ABX-1431 is currently entering clinical studies for neurological disorder as well as for other indications, such as neuromyeltis optica and multiple sclero
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | ABX-1431 |
|---|---|
| Iupac 化学名称 | 1,1,1,3,3,3-Hexafluoropropan-2-yl-4-[[2-(pyrrolidin-1-yl)-4-(trifluoromethyl)phenyl]methyl]piperazine-1-carboxylate |
| 同义词 | ABX-1431; ABX 1431; ABX1431; |
| 英文同义词 | ABX-1431; ABX 1431; ABX1431; |
| 分子式 | C20H22F9N3O2 |
| 分子量 | 507.4 |
| Smile | O=C(N1CCN(CC2=CC=C(C(F)(F)F)C=C2N3CCCC3)CC1)OC(C(F)(F)F)C(F)(F)F |
| InChiKey | SQZJGTOZFRNWCX-UHFFFAOYSA-N |
| InChi | InChI=1S/C20H22F9N3O2/c21-18(22,23)14-4-3-13(15(11-14)31-5-1-2-6-31)12-30-7-9-32(10-8-30)17(33)34-16(19(24,25)26)20(27,28)29/h3-4,11,16H,1-2,5-10,12H2 |
| Cas号 | 1446817-84-0 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | 固体粉末 |
|---|---|
| 纯度 | 98% Min. |
| 存储 | 短期（几天到几周）为0-4摄氏度，长期（几个月）为-20摄氏度 |
| 可溶性 | 可溶于DMSO |
| 处理方式 | |
| 海关编码 |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Jiang M, van der Stelt M. Activity-Based Protein Profiling Delivers Selective
Drug Candidate ABX-1431, a Monoacylglycerol Lipase Inhibitor, To Control Lipid
Metabolism in Neurological Disorders. J Med Chem. 2018 Oct 25;61(20):9059-9061.
doi: 10.1021/acs.jmedchem.8b01405. Epub 2018 Oct 11. PubMed PMID: 30354159;
PubMed Central PMCID: PMC6204598.
2: Cisar JS, Weber OD, Clapper JR, Blankman JL, Henry CL, Simon GM, Alexander JP,
Jones TK, Ezekowitz RAB, O'Neill GP, Grice CA. Identification of ABX-1431, a
Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for
Treatment of Neurological Disorders. J Med Chem. 2018 Oct 25;61(20):9062-9084.
doi: 10.1021/acs.jmedchem.8b00951. Epub 2018 Aug 23. PubMed PMID: 30067909.
