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ABT-639

Catalog No.: 6111011
Cas No.: 1235560-28-7
Purity : 98% 
6111011 - ABT-639 | CAS 1235560-28-7

Catalog number : 6111011

CAS number : 1235560-28-7

分子式 : C20H20ClF2N3O3S 

分子量 : 455.91 

Iupac 化学名称 : ABT-639 

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同义词ABT639; ABT 639 
英文同义词ABT639; ABT 639 
分子式C20H20ClF2N3O3S 
分子量455.91 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
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ABT-639 is a novel, peripherally acting, selective T-type Ca2+ channel blocker. ABT-639 blocks recombinant human T-type (Cav3.2) Ca2+ channels in a voltage-dependent fashion (IC50 = 2 M) and attenuates LVA currents in rat DRG neurons (IC50 = 8 M).

ABT-639 is significantly less active at other Ca2+ channels (e.g. Cav1.2 and Cav2.2) (IC50 > 30 M). ABT-639 has high oral bioavailability (%F = 73), low protein binding (88.9%) and a low brain:plasma ratio (0.05:1) in rodents.



 

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