AB-680
编号: 2091501
Cas号: 2105904-82-1
纯度: 98% Min.
AB-680 is highly potent, reversible and selective CD73 inhibitor. AB680 to be a reversible, slow-onset competitive inhibitor of human CD73 with a Ki of 5 pM. Clinical candidates of this potency are uncommon and deserve special consideration during lead optimization. AB680 is the first small molecule CD73 inhibitor in the clinic.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | AB-680 |
|---|---|
| Iupac 化学名称 | (((((2R,3S,4R,5R)-5-(6-chloro-4-(((S)-1-(2-fluorophenyl)ethyl)amino)-1H-pyrazolo[3,4-b]pyridin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)methyl)phosphonic acid |
| 同义词 | AB-680 ; AB 680 ; AB680 ; |
| 英文同义词 | AB-680 ; AB 680 ; AB680 ; |
| 分子式 | C20H24ClFN4O9P2 |
| 分子量 | 580.8269 |
| Smile | O=P(CP(O)(O)=O)(O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=C(Cl)C=C3N[C@H](C4=CC=CC=C4F)C)=C3C=N2)O1 |
| InChiKey | MFYLCAMJNGIULC-KCVUFLITSA-N |
| InChi | InChI=1S/C20H24ClFN4O9P2/c1-10(11-4-2-3-5-13(11)22)24-14-6-16(21)25-19-12(14)7-23-26(19)20-18(28)17(27)15(35-20)8-34-37(32,33)9-36(29,30)31/h2-7,10,15,17-18,20,27-28H,8-9H2,1H3,(H,24,25)(H,32,33)(H2,29,30,31)/t10-,15+,17+,18+,20+/m0/s1 |
| Cas号 | 2105904-82-1 |
| 相关CAS号 | 2105904-82-1 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | Solid powder |
|---|---|
| 纯度 | 98% Min. |
| 存储 | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| 可溶性 | Soluble in DMSO |
| 处理方式 | Avoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation. |
| 运输条件 | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| 海关编码 |
Coming soon.
| Targets | CD73 inhibitor |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Bowman CE, da Silva RG, Pham A, Young SW. An Exceptionally Potent Inhibitor of
Human CD73. Biochemistry. 2019 Aug 6;58(31):3331-3334. doi:
10.1021/acs.biochem.9b00448. Epub 2019 Jul 23. PubMed PMID: 31334635.
