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A2793

编号: 20286
Cas号: 88349-90-0
纯度: 98% Min.

A2793 is an inhibitor of TRESK (IC50 value of 6.8 μM for mTRESK). A2793 inhibited TWIK-related acid-sensitive K+ channel (TASK)-1 (100 µM, 53.4% ± 13, 5%, n = 5).

仅供研究使用。 我们不向患者出售。

化学信息

名称A2793
Iupac 化学名称Ethyl 2-[(5-chloroquinolin-8-yl)oxy]acetate
同义词A2793; A-2793; A2793;
英文同义词A2793; A-2793; A2793;
分子式C13H12ClNO3
分子量265.69
SmileO=C(OCC)COC1=C2N=CC=CC2=C(Cl)C=C1
InChiKeyJEMXUSHXYOXNFL-UHFFFAOYSA-N
InChiInChI=1S/C13H12ClNO3/c1-2-17-12(16)8-18-11-6-5-10(14)9-4-3-7-15-13(9)11/h3-7H,2,8H2,1H3
Cas号88349-90-0
相关CAS号

订购信息

包装价格库存纯度备货期
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外观性状固体粉末
纯度98% Min.
存储短期(几天到几周)为0-4摄氏度,长期(几个月)为-20摄氏度
可溶性溶于DMSO
处理方式
运输条件作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周.
海关编码
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1: Lengyel M, Erdélyi F, Pergel E, Bálint-Polonka Á, Dobolyi A, Bozsaki P, Dux M, Király K, Hegedűs T, Czirják G, Mátyus P, Enyedi P. Chemically Modified Derivatives of the Activator Compound Cloxyquin Exert Inhibitory Effect on TRESK (K2P18.1) Background Potassium Channel. Mol Pharmacol. 2019 Jun;95(6):652-660. doi: 10.1124/mol.118.115626. Epub 2019 Apr 12. PMID: 30979812.

2: Bosman WM, Bronkhorst MW. Een vrouw met een pijnlijke enkel [A woman with a painful ankle]. Ned Tijdschr Geneeskd. 2012;156(4):A2793. Dutch. PMID: 22278033.

3: Oehlmann M, Score AJ, Blow JJ. The role of Cdc6 in ensuring complete genome licensing and S phase checkpoint activation. J Cell Biol. 2004 Apr 26;165(2):181-90. doi: 10.1083/jcb.200311044. Epub 2004 Apr 19. PMID: 15096526; PMCID: PMC2172031.

4: Prokhorova TA, Blow JJ. Sequential MCM/P1 subcomplex assembly is required to form a heterohexamer with replication licensing activity. J Biol Chem. 2000 Jan 28;275(4):2491-8. doi: 10.1074/jbc.275.4.2491. PMID: 10644704; PMCID: PMC3626232.


化学结构

20286 - A2793 | CAS 88349-90-0

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