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A-366

Catalog No.: 16122743
Cas No.: 1527503-11-2
Purity : 98% 
16122743 - A-366 | CAS 1527503-11-2

Catalog number : 16122743

CAS number : 1527503-11-2

分子式 : C19H27N3O2 

分子量 : 329.44 

Iupac 化学名称 : A-366 

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同义词N/A 
英文同义词N/A 
分子式C19H27N3O2 
分子量329.44 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
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A-366 is a potent and selective G9a/GLP histone lysine methyltransferase inhibitor with IC50 of 3.3nM, exhibiting >1000-fold selectivity for G9a/GLP over 21 other methyltransferases.A-366 has significantly less cytotoxic effects on the growth of tumor cell lines compared to other known G9a/GLP small molecule inhibitors despite equivalent cellular activity on methylation of H3K9me2. Treatment of various leukemia cell lines in vitro results in marked differentiation and morphological changes of these tumor cell lines 

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