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5-Iodotubercidin

Catalog No.: 16122729
Cas No.: 24386-93-4
Purity : 98% 
16122729 - 5-Iodotubercidin | CAS 24386-93-4

Catalog number : 16122729

CAS number : 24386-93-4

分子式 : C11H13IN4O4 

分子量 : 392.15 

Iupac 化学名称 : 5-Iodotubercidin 

Smile : c1c(c2c(ncnc2n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N)I

InChiKey : WHSIXKUPQCKWBY-IOSLPCCCSA-N

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同义词NSC 113939, 5-Itu 
英文同义词NSC 113939, 5-Itu 
分子式C11H13IN4O4 
分子量392.15 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
Smilec1c(c2c(ncnc2n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N)I
InChiKeyWHSIXKUPQCKWBY-IOSLPCCCSA-N
InChiInChI=1S/C11H13IN4O4/c12-4-1-16(10-6(4)9(13)14-3-15-10)11-8(19)7(18)5(2-17)20-11/h1,3,5,7-8,11,17-19H,2H2,(H2,13,14,15)/t5-,7-,8-,11-/m1/s1
MDLMFCD00055131
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5-Iodotubercidin is a potent adenosine kinase inhibitor with IC50 of 26 nM. It inhibits nucleoside transporter, CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC.5-Iodotubercidin(Itu) is a genotoxic drug that activates the Atm-p53 pathway and has anti-tumor activity. Itu is unique compared to other nucleoside analogs in the way that it induces G2 arrest in a p53 -dependent manner. Moreover, at higher doses, Itu might activate p53-independent pathways, which may cooperate with p53 to kill cells and inhibit tumor growth. Incorporation of Itu metabolite into DNA causes DNA breaks, which triggers the DNA damage response. Itu might be a potential chemotherapeutic drug with distinct working mechanisms 

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