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3PO

Catalog No.: 161227109
Cas No.: 13309-08-5
Purity : 98% 
161227109 - 3PO | CAS 13309-08-5

Catalog number : 161227109

CAS number : 13309-08-5

分子式 : C13H10N2O 

分子量 : 210.236 

Iupac 化学名称 : 3PO 

Smile : c1cc(cnc1)/C=C/C(=O)c2ccncc2

InChiKey : UOWGYMNWMDNSTL-ONEGZZNKSA-N

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同义词N/A 
英文同义词N/A 
分子式C13H10N2O 
分子量210.236 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
Smilec1cc(cnc1)/C=C/C(=O)c2ccncc2
InChiKeyUOWGYMNWMDNSTL-ONEGZZNKSA-N
InChiInChI=1S/C13H10N2O/c16-13(12-5-8-14-9-6-12)4-3-11-2-1-7-15-10-11/h1-10H/b4-3+
MDLMFCD00224002
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3PO is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) inhibitor. 3PO reduces glycolytic flux and suppresses glucose uptake. 3PO may be useful agents in combination with other drugs that inhibit cancer cell proliferation. PFKFB3 inhibitors suppress glucose uptake, which in turn causes an increase in autophagy. The addition of selective inhibitors of autophagy to 3PO and its more potent derivatives may prove useful as rational combinations for the treatment of cancer. 

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