3-(methylsulfonyl)propanenitrile
编号: 24044
Cas号: 54863-37-5
纯度: 98% Min.
Dapansutrile is a potent, orally active and selective NLRP3 inflammasome inhibitor. Dapansutrile has anti-inflammatory activity and decreases immune factor levels. Dapansutrile can be used for research of inflammatory diseases.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | 3-(methylsulfonyl)propanenitrile |
|---|---|
| Iupac 化学名称 | 3-(Methylsulfonyl)propanenitrile |
| 同义词 | PimasertibHydrochloride;OLT1177;DAPANSUTRILE;OLT1177;OLT-1177;OLT1177;:3-(methylsulfonyl)propanenitrile;Dapansutrile(OLT1177);Propanenitrile,3-(methylsulfonyl)-;3Chemicalbook-Methanesulfonylpropanenitrile;anti-inflammatory,infarct,inhibit,neurologicaldecline,NLRP3inflammasome,Dapansutrile,cardiacfunction,Inhibitor,NOD-likeReceptor(NLR) |
| 英文同义词 | PimasertibHydrochloride;OLT1177;DAPANSUTRILE;OLT1177;OLT-1177;OLT1177;:3-(methylsulfonyl)propanenitrile;Dapansutrile(OLT1177);Propanenitrile,3-(methylsulfonyl)-;3Chemicalbook-Methanesulfonylpropanenitrile;anti-inflammatory,infarct,inhibit,neurologicaldecline,NLRP3inflammasome,Dapansutrile,cardiacfunction,Inhibitor,NOD-likeReceptor(NLR) |
| 分子式 | C4H7NO2S |
| 分子量 | 133.17 |
| Smile | N#CCCS(=O)(C)=O |
| InChiKey | LQFRYKBDZNPJSW-UHFFFAOYSA-N |
| InChi | InChI=1S/C4H7NO2S/c1-8(6,7)4-2-3-5/h2,4H2,1H3 |
| Cas号 | 54863-37-5 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | Off-white solid |
|---|---|
| 纯度 | 98% Min. |
| 存储 | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| 可溶性 | Soluble in DMSO |
| 处理方式 | Refer to MSDS |
| 运输条件 | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| 海关编码 | 2934200090 |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
[1]. Sánchez-Fernández A, et, al. OLT1177 (Dapansutrile), a Selective NLRP3 Inflammasome Inhibitor, Ameliorates Experimental Autoimmune Encephalomyelitis Pathogenesis. Front Immunol. 2019 Nov 1;10:2578.
[2]. Toldo S, et, al. The NLRP3 Inflammasome Inhibitor, OLT1177 (Dapansutrile), Reduces Infarct Size and Preserves Contractile Function After Ischemia Reperfusion Injury in the Mouse. J Cardiovasc Pharmacol. 2019 Apr;73(4):215-222.
