1V209
1V209, also known as TLR7 agonist T7, is a novel Toll-like receptor 7 (TLR7) agonist, eliciting the nonspecific antitumor responses and strengthening the specific humoral and cellular immune responses.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | 1V209 |
|---|---|
| Iupac 化学名称 | 4-[[6-Amino-7,8-dihydro-2-(2-methoxyethoxy)-8-oxo-9H-purin-9-yl]methyl]-benzoic acid |
| 同义词 | TLR7 agonist T7; 1V209; 1V-209; 1V 209; |
| 英文同义词 | TLR7 agonist T7; 1V209; 1V-209; 1V 209; |
| 分子式 | C16H17N5O5 |
| 分子量 | 359.34 |
| Smile | O=C(O)C1=CC=C(CN2C(NC3=C(N)N=C(OCCOC)N=C23)=O)C=C1 |
| InChiKey | ATISKRYGYNSRNP-UHFFFAOYSA-N |
| InChi | InChI=1S/C16H17N5O5/c1-25-6-7-26-15-19-12(17)11-13(20-15)21(16(24)18-11)8-9-2-4-10(5-3-9)14(22)23/h2-5H,6-8H2,1H3,(H,18,24)(H,22,23)(H2,17,19,20) |
| Cas号 | 1062444-54-5 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | 固体粉末 |
|---|---|
| 纯度 | 98% Min. |
| 存储 | 短期（几天到几周）为0-4摄氏度，长期（几个月）为-20摄氏度 |
| 可溶性 | 溶于DMSO |
| 处理方式 | |
| 运输条件 | 作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周. |
| 海关编码 |
| Targets | |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Zhang N, Jin G, Jin Z, Liu B, Peng B, Gao N, Hu Y, Tang L. [Combination of TLR7 agonist T7-ethacrynic acid conjugate with ROR1 has a stronger anti-breast cancer effect]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016 Jul;32(7):876-80. Chinese. PubMed PMID: 27363264.
2: Wang XD, Gao NN, Diao YW, Liu Y, Gao D, Li W, Wan YY, Zhong JJ, Jin GY. Conjugation of toll-like receptor-7 agonist to gastric cancer antigen MG7-Ag exerts antitumor effects. World J Gastroenterol. 2015 Jul 14;21(26):8052-60. doi: 10.3748/wjg.v21.i26.8052. PubMed PMID: 26185376; PubMed Central PMCID: PMC4499347.
3: Lin G, Wang X, Yi W, Zhang C, Xu G, Zhu X, Cai Z, Liu Y, Diao Y, Lin MC, Jin G. A conjugate of octamer-binding transcription factor 4 and toll-like receptor 7 agonist prevents the growth and metastasis of testis embryonic carcinoma. J Transl Med. 2015 May 20;13:166. doi: 10.1186/s12967-015-0524-y. PubMed PMID: 25990580; PubMed Central PMCID: PMC4455914.
