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(+)-JQ1

Catalog No.: 16070105
Cas No.: 1268524-70-4
Purity : 98% by HPLC 
16070105 - (+)-JQ1 | CAS 1268524-70-4

Catalog number : 16070105

CAS number : 1268524-70-4

分子式 : C23H25ClN4O2S 

分子量 : 456.99 

Iupac 化学名称 : tert-butyl (S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 

Smile : ClC1=CC=C(C=C1)C1=N[C@H](C=2N(C3=C1C(=C(S3)C)C)C(=NN2)C)CC(=O)OC(C)(C)C

InChiKey : DNVXATUJJDPFDM-KRWDZBQOSA-N

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同义词(+)JQ1; Bromodomain Inhibitor 
英文同义词(+)JQ1; Bromodomain Inhibitor 
分子式C23H25ClN4O2S 
分子量456.99 
外观Solid powder 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileClC1=CC=C(C=C1)C1=N[C@H](C=2N(C3=C1C(=C(S3)C)C)C(=NN2)C)CC(=O)OC(C)(C)C
InChiKeyDNVXATUJJDPFDM-KRWDZBQOSA-N
InChiInChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m0/s1
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(+)-JQ1 is a BET potent BET bromodomain Inhibitor. Bromodomain and extra terminal domain (BET) proteins are important epigenetic regulators facilitating the transcription of genes in chromatin areas linked to acetylated histones. JQ1 has antiproliferative activity against many cancers, mainly through inhibition of c-MYC and upregulation of p21. JQ1 suppresses tumor growth through downregulating LDHA in ovarian cancer. JQ1 suppresses growth of pancreatic ductal adenocarcinoma in patient-derived xenograft models. JQ1 disrupts human dendritic cell maturation by inhibiting STAT5 

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