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(+)-JQ1

编号: 16070105
Cas号: 1268524-70-4
纯度: 98% by HPLC 

(+)-JQ1 is a BET potent BET bromodomain Inhibitor. Bromodomain and extra terminal domain (BET) proteins are important epigenetic regulators facilitating the transcription of genes in chromatin areas linked to acetylated histones. JQ1 has antiproliferative activity against many cancers, mainly through inhibition of c-MYC and upregulation of p21. JQ1 suppresses tumor growth through downregulating LDHA in ovarian cancer. JQ1 suppresses growth of pancreatic ductal adenocarcinoma in patient-derived xenograft models. JQ1 disrupts human dendritic cell maturation by inhibiting STAT5 

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化学信息

名称(+)-JQ1
Iupac 化学名称tert-butyl (S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 
同义词(+)JQ1; Bromodomain Inhibitor 
英文同义词(+)JQ1; Bromodomain Inhibitor 
分子式C23H25ClN4O2S 
分子量456.99 
SmileClC1=CC=C(C=C1)C1=N[C@H](C=2N(C3=C1C(=C(S3)C)C)C(=NN2)C)CC(=O)OC(C)(C)C
InChiKeyDNVXATUJJDPFDM-KRWDZBQOSA-N
InChiInChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m0/s1
Cas号1268524-70-4
相关CAS号

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外观性状Solid powder 
纯度98% by HPLC 
存储-20 ºC for 3 years 
可溶性Soluble in DMSO 
处理方式
运输条件Shipped under ambient temperature 
海关编码
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Targets
Mechanism
Cell study
Animal study
Clinical study
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化学结构

16070105 - (+)-JQ1 | CAS 1268524-70-4

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