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(±)-Bisoprolol hemifumarate

Catalog No.: 6111106
Cas No.: 104344-23-2
Purity : 98% 
6111106 - (±)-Bisoprolol hemifumarate | CAS 104344-23-2

Catalog number : 6111106

CAS number : 104344-23-2

分子式 : C40H66N2O12 

分子量 : 766.96 

Iupac 化学名称 : (±)-Bisoprolol hemifumarate

Smile : CC(C)NC[C@H](COc1ccc(cc1)COCCOC(C)C)O

InChiKey : VHYCDWMUTMEGQY-QGZVFWFLSA-N

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同义词Bisoprolol hemifumarate salt 
英文同义词Bisoprolol hemifumarate salt 
分子式C40H66N2O12 
分子量766.96 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
SmileCC(C)NC[C@H](COc1ccc(cc1)COCCOC(C)C)O
InChiKeyVHYCDWMUTMEGQY-QGZVFWFLSA-N
InChiInChI=1S/C18H31NO4/c1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4/h5-8,14-15,17,19-20H,9-13H2,1-4H3/t17-/m1/s1
MDLMFCD08063387
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Bisoprolol is a selective type 1 adrenergic receptor blocker.

Bisoprolol, on beta 1-adrenoceptor peptide induced autoimmune myocardial damage. In the animal model of autoimmune cardiomyopathy induced by active immunization of rabbits with beta 1-adrenoceptor peptide, bisoprolol was given at a dose of 3 mg/day throughout the study period. Our results showed high titer of anti-beta 1-adrenoceptor antibody in the immunized group throughout the study but not in the group receiving only bisoprolol [1]. Bisoprolol administration resulted in a significant reduction in HR reaching 60.3 +/- 1.4 bpm at VT of 500 mL (compared to 70.5 +/- 1.8 bpm with placebo, P < 0.001). Changes in HP were also significant with an increase in HP reaching 1004.5 +/- 22.2 msec at this controlled VT (compared to 860.3 +/- 21.5 msec with placebo, P < 0.001) .


 

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